Wayfinding and orientation problems for visitors of large buildings such as hospitals and offices still occur due to an insufficient orientation quality of the building. The building layout is one of the major factors affecting the orientation quality of buildings. Easy to use indicators of layout complexity with respect to wayfinding and orientation might be useful to enable the communication and support of design decisions and of POE-analyses. Some published indicators for this purpose are assessed in this paper: the STAGG-method, the labyrinth-factor, and the lCD. The STAGG-method is intended for the evaluation of health care facilities, with orientation quality as one of the evaluation aspects. This orientation quality is based on the number of choice possibilities along the routes towards a number of predefined destinations for the different user groups. For the labyrinth_factor the number of route direction changes are counted on a floor from the vertical transport to the destination, with a higher weighting factor for angles not equal 900. A fixed criterion value is specified. The lCD (= InterConnection Density) is based on counting for each node the number of corridors (connections to other nodes), and averaging them over the nodes of the floor plan. In the paper firstly these indicators are analyzed for their basic theoretical assumptions, and secondly, for possible problems and constraints when applied at detailed floor plans. The results show that for all three methods, some adaptations are necessary to improve the applicability. Only in the STAGG-method the connection of several floors is included. The lCD turns out to be not always sensitive for major differences in building layouts: for some layout types any number of corridors can be added without affecting the resulting lCD value. Third, a wayfinding experiment was run in two university buildings with a different type of layout, as an attempt to test the validity of the STAGG-method and the labyrintfactor as indicators for the orientation quality. For both indicators the observed wayfinding errors are positively related to increasing indicator values, as expected. However, different situations with an equal indicator value do not correspond to equal wayfinding performance. Other aspects have to be taken into consideration also to arrive at a valid measure of layout complexity.