Extreme environmental and social conditions in polar and circumpolar regions present great challenges to human beings. The conditions are much harsher and the challenge is much greater for those who have to spend extended periods of time at remote stations in isolated and confined environments (ICEs). While high task motivation and unusual scenic landscapes help humans adapt to the harsh conditions, appropriate design and management of the stations can play a significant role in reducing stress and adverse effects of ICEs on human well-being. Recently, the authors of this paper were principal members of a team that designed a new research station at the summit of Greenland for the Office of Polar Programs of the U. S. National Science Foundation. The station is to host scientists and their support personnel working on research projects at the site through winter seasons. Drawing from literature studies and design process of the station, this paper discusses critical issues pertinent to the design of built habitats in isolated and confined environments (ICEs). Several design considerations of the new station at the summit of Greenland are also reported. Findings of preliminary evaluations by its initial users shortly after the station was built and occupied are also reported. The paper concludes with a suggestion that nine issues should be appropriately addressed in the design and evaluation of similar stations in polar and circumpolar regions in the future from an environmental behavioral perspective. The nine issues are: privacy, social space, separation between private and public as well as spaces of distinct functions, flexibility in interior environment, means of personalization, noise, lighting, visual stimuli, and perception of safety. The paper argues that appropriate design considerations addressing these issues will make the habitat become more than merely a survival protection. It can help ease the adaptation process, alleviate stresses associated with polar and circumpolar ICEs, maintain a higher level of well-being among its inhabitants.