"This paper concerns the positive effects of environmental "humanization" in paediatric hospital on their users. The target of "humanizing hospital spaces" (Shumaker and Pequegnat, 1989), or "more humane hospital environments" (Nagasawa, 2000), refers to spatial, physical and functional design requirements that health care environments should possess for both (i) reducing the stress level which can be very high for both patients and staff, given their daily contact with disease, pain and (in some cases) death, and (ii) promoting and increasing the well-being and the quality of life of patients and staff. As regards the first point, it seems demonstrated that a poor interior design could generate a stressing environment which frustrates rather than facilitates goal-achievement for all the social actors involved (Stokols, 1979). On the contrary, design elements which elicit perceptual consistence, control over space, clear affordance, and restorativeness (Evans and McCoy, 1998) are capable to both moderate the stress level and produce an healing effect (e.g., see Ulrich, 1984)."