Person-environment (environment-bahavior) studies in the past have primarily employed methods drawn from sociology, anthropology, and psychology. The neurosciences now offer a new approach for design and design research. Neuroscience theory, findings and techniques -including PET and MRI scans -present us with intriguing new ways to better understand person-environment interactions. This paper presents an approach to designing for people with Alzheimer's disease employing such a neuroscience paradigm to augment the older « user needs » paradigme.scipline. The case study demonstrates how specific design guidelines as well as operational and communication approaches can be generated using an understanding of brains of those with Alzheimer's disease.