"This paper aims to explore the nature and validitiy of conceptions of archi-tectural space, which are the outcome of cultural symbiosis, generated ei-ther by a process of balanced inter-influences or by a conscious act of crea-tivity.A distinction should be made between universal spatial archetypes and cul-ture conditioned ones. The former derive from the way we perceive, relateto and organize the physical environment and conduce to topologicaly simi-lar mass-void configurations (the Western Court Building an the EasternKhan as embodiment of the idea of enclosed space).These generic constructs are culturally qualified and transformed throughspecific concepts of spatial order, which differ in place and time, there cat-egories will be discussed:TRASPLANTED SPACE resluting from cultural impostion or assertion (i.e.early Colonial architecture in Ibero-America, or Crusader and 19th Centu-ry architecture in Jerusalem).CROSS CULTURAL SPACE generated by lengthy processes or interactionproducing multi-layered and idiosincratic phenomena like American Ba-roque, Mudejar architecture or the singular case of the Carmenes in Grana-da, Spain.TRANSCULTURAL SPACE CONCEPTIONS and their actuality in the era of the"Global Village". Conscious symbiosis between abstract-universal constr-cuts and culturally rooted ones. Historical precedent, like Palladlanism inEngland will be compared with contemporary developments, particularythrough the metamorphoses of the Modern Movement in Mediterraneancountries and the question of regionalism. Erich Mendelson's paradigmatic work in Germany, Israel and the United-States will be analyzed as an example of the quest for this symbiotic condi-tion in architectural space."