A transactional consideration of human-environment systems holds that the various aspects of these systems are mutually defining (Altman & Rogoff, 1987). Experiential aspects of natural and built environments exemplify this; experiences of nature often are described with some reference to the experience of built living spaces. This mutual dependency is a pervasive theme in a large, multidisciplinary body of research that touches on nature experience in a variety of ways. In treating this theme, the paper starts by discussing evolutionary and cultural theoretical perspectives on factors guiding the emergence of environmental preferences. Seen in a broad temporal context, evolutionary and cultural determinants of preference reflect the mutualism of the natural and built aspects of the human-environment systems they respectively represent. Literature is then reviewed to highlight the reciprocation between nature experience and the experience of built, often urban, environments. Patterns of environmental preferences, motivations driving natural environment experiences, and benefits attributed to those experiences all speak to the existence of these experiential bonds. The paper closes with a consideration of strategies for future research.