This study is structured around three parallel themes: the loss of architecture’s aesthetic significance which aims to discuss the nature and the limits of architecture as an art in a general epistemological perspective; the problematic nature of architecture, after modern and postmodern effects in the bourgeois society within the Higher Education Buildings and the life of the young; and the aesthetical concepts in the architecture of higher education buildings and its political implications with the questions concerning the essence, form and culture in aesthetics. In our times, there has been a marked tendency to attribute the loss of architecture’s poetic significance to modernism and rationality. As a result, the architecture, art and aesthetics become far away from human. Different philosophical perspectives such as phenomenology and poststructuralism surprisingly converge on accusing modernism and its philosophical foundations for depriving architecture of its mythical rhetorical substance giving prominence to logos, i.e., to what counts as universal objective knowledge. Both viewpoints fail to recognize the Architectural Aesthetics of the problem concerning arts’ alienation from culture: the former by unrealistically suggesting a revival of pre-enlightened consciousness; the latter by renouncing rationality and history as futile attempts to overcome ‘the will to power’ which they assume to be an unsurpassable part of human existence. In this study, the significance of Aesthetics in the Art of Architecture, is discussed from the point of view of a historical-philosophical framework, developed from Platon, Kant, Hegel, B:Croce and our times. The accept of an universal architecture is negative as Aesthetical view, and whereas the industrial society aimed for universality and homogeneity, the information society will aim for multiplicity, as Architecture will be achieved to protect the differences of Architectures and Cultures and their different Aesthetical values. It is maintained that the loss of protection for local Aesthetical values in the Art of Architecture during the Enlightenment period and later, is part of a complex set of social, cultural, technical transformations that have brought about art’s separation from life in modern bourgeois society. An important part of this work is devoted to the discussion of the availability to social transformation and cultural changes in the Architecture of higher education and the environment of youth as Aesthetics of Architecture and the changes of design in the essence of Aesthetics, form and the results of the relations between Aesthetical concepts and Architecture of Higher Education Buildings. A re-assessment of the period after modernism, postmodernism and deconstruction, has been made regarding their position within the broader question of Aesthetics and Art’s autonomies. In a design, the most important factors to be taken into consideration are the essence, form and culture. For this reason, nowadays, to understand the essence, form and culture for university buildings environment and during the process of design of a certain item (object, building, environment, etc.) in an aesthetic manner as functional as possible for young people and for staff, it must be understood well some systems of culture in the world. Investigating whether to preserve this actual reality and to produce an aesthetic environment with a conformist idea, or change completely this system and going out from the actual reality and by a revolutionary manner to a new culture and reaching to a new horizon- to virtual reality which is not existing. It is there that the basis of the problem exists. Key words: Aesthetics in Architecture for Higher Education Buildings, Postmodernism, Essence (Function), Form, Culture.