Globalization has become a necessary trend for the 21st century. How cities can be competitive becomes an important issue nowadays for governments around the world. In an UN report, it is predicted that in 2050 over 50% of the world population will be living in urban areas. Consequently, the quality of urban life will play an important role in light of global city competition. In the new era, how to objectively measure people’s perceptions and attitudes towards their living environment becomes an urgent and appropriate task. Using the indicators of quality of life to evaluate the living environment of a certain area can therefore be adopted as an appropriate policy strategy and can be used as the basis for increasing the competitiveness of that area. This work acquires permission from the Detroit Area Study (DAS, University of Michigan) team to include Tainan as one of the global comparison samples. Therefore, using the DAS as the basis and using the literature of global city, sustainable development (SD) and city competitiveness to examine the quality of life in Tainan can therefore provide an evaluation system and a monitoring mechanism for evaluating the quality of urban life. Subsequently, results can be adopted by Tainan and other governments in Taiwan to increase city competitiveness and further to achieve the sustainable development goal.