Aim: to investigate factors impacting on inner city high-rise residents' health and wellbeing. Objectives: (i) to discover the impacts of inner city high-rise living on individuals' health and wellbeing and (ii) to complete Australian research that investigates the impacts of access to natural environments for people living in inner city high-rise developments. Despite recognition of the negative health effects associated with high-rise living, in recent years there has been an almost three-fold increase in the number of inner city high-rise occupants in Melbourne and Sydney. With the transition from traditional detached house occupancy to high density apartment living, opportunities for contact with the natural environment have been reduced for many city dwelling Australians. Contact with 'nature', such as urban parks, gardens, waterfronts and pets, has been shown to minimize some of the negative effects of living in the inner city. Research suggests that contact with nearby 'nature' can enhance high-rise residents' physical and mental health and wellbeing. This mixed-methods project comprised two forms of data collection: Phase 1: quantitative self-completed questionnaires and Phase 2: qualitative semi-structured interviews. Phase 1 involved surveying 221 high-rise residents to determine associations between high-rise living and health and wellbeing and access to natural environments and health and wellbeing. Participants' varied in gender, age, socio-economic status, health status, tenure, city of residence, length of residence and proximity to natural environments. Phase 2 involved interviewing 30 of the surveyed participants to explore in detail their understandings and experiences of high-rise living and access to natural environments. This paper presents findings from Phase 2 of the project. Thematic analysis of the interview data generated 7 broad categories of factors found to impact on participants' health and wellbeing (positively and negatively). These categories were: 1. Accessibility, 2. Management, 3. Safety and Security, 4. Design and Development, 5. Connections, Choice and Control, 6. Community Infrastructure and 7. Social Exclusion. The qualitative findings supported findings from Phase 1 of the project and indicated that whilst access to natural environments enhances high-rise residents' health and wellbeing, a range of other factors are also influential. Findings generated from this exploratory project provide some evidence to suggest that for disadvantaged populations (e.g. public housing tenants), the availability of a park, garden or waterfront, can enhance health and wellbeing. Future research could focus on high-rise living in different countries to explore cross-cultural comparisons.