This paper aims to present a critical review of socio-ecological models of work stress as related to healthcare staff alongside a parallel review of literature relating to satisfaction with office work environments. A model is then presented which attempts to synthesise research from the sociological and architectural disciplines to provide an integrated evaluation tool for analysis of the impact of the built environment on stress and coping mechanisms of healthcare staff. Schaefer and Moos proposed a theoretical model of work stressors in healthcare settings indicating relationships between self schema, organizational culture, work stressors, coping mechanisms and wellbeing with reference to Karasek (Schaefer & Moos 1993; Karasek 1979). Jones and Johnston amended this model to address the transactional association of the variables (Jones & Johnston 2000) still identifying their model as socio-ecological while making little reference to the impact of the built environment. Workplace evaluation theories have been largely developed in office environments by Becker, Brill and Sundstrom among others (Becker, 1981; Brill, 1998; Sundstrom 1986). Archea addressed the relationship between the built environment and social behavior, although not specifically behavior in the workplace (Archea, 1977). Studies of the healthcare environment have largely focused on patient facilities or on the organizational culture and working practices of staff. This paper is an attempt to interpret and apply theories and models from the various domains to understand the impact of the built environment on staff wellbeing in healthcare environments. An extensive literature review examining models of work stress and satisfaction in nursing, sociology, psychology, environment and behavior and architectural domains was undertaken. 228 nurses in ten different locations throughout UK were given self report questionnaires with questions relating to wellbeing, satisfaction, perceived stress, control, working environment, staff facilities and organizational culture. Data was analyzed for evidence supporting an amended model of the relationship between work stress and the built environment. Statistical analysis revealed significant correlation between satisfaction with staff facilities and job satisfaction. Access to staff rest areas was ranked closely behind air quality and as a factor contributing to personal health problems. In open comments, interviews and focus groups the provision of appropriate staff rest areas was highlighted as indicative of the value management placed on nursing staff.