The study looks at the spatial and social-economic impacts of home-based work on the function and design, at domestic and urban scale, of low-income housing schemes. Methodological procedures consisted of postoccupancy evaluation and configuration analysis of six low-income housing schemes comprised of different dwelling types, located in the metropolitan region of Porto Alegre, Brazil. Data was collected through questionnaires, interviews, observations and physical measurements. Space syntax measures such as integration of axial lines and visibility graph were used to analyze the spatial configuration of home-based work. Results show that part of household income generation originate from entrepreneurial activities carried out in the dwelling, resulting in a number of physical modifications in the dwelling as well as the creative usage of space and occupation of common areas. The type and quantity of modifications taking place are related to the degree of spatial flexibility, according to each dwelling type, which affected residents' satisfaction with the housing scheme. Dwelling location within the urban area and neighborhood, and its linkages to public infrastructure impact the characteristics of home-based work and the usage of the dwelling for income generation. The provision of adequate design attributes to allow for home-based incomegenerating activities calls for an ample discussion on the findings as they might help to base guidelines for good practices in the design of social housing.