Latin American megacities are subject to unprecedented transformation processes at speed and scale such as social, economical, institutional, spatial, cultural and ecological ones. This is also the case of Santiago de Chile where these transformations are accompanied by an intensive socio-spatial differentiation which has a powerful impact on land use patterns. Concerning this matter, the traditional large scale of socio-economic residential segregation has dominated the urban landscape of Santiago de Chile for a long time. Nevertheless, at present, these traditional patterns have been undergoing transformations in two main aspects: firstly, on a geographical scale at which segregation takes place —in some cases decreasing and in others increasing—, and secondly, on a social scale where segregation’s ‘malignancy’ grows. These two contrary patterns seem to be associated with the globalization process, the liberalization of urban land markets, and the flexibility of labour markets which the Chilean economy has undergone since the 80’s reforms. Based on these tendencies, the new urban structure within Santiago de Chile shows both, new opportunities and social risks for different social groups. Therefore, the emergence of gated communities for medium and high-income groups not located in their traditional areas of residence but rather close to lower income neighbourhoods has been an opportunity for social mixing and social integration processes of former poor areas. Beside these opportunities, social housing programmes have contributed to social exclusion – one dimension of social risks – by building social homogenous ‘ghettos’ at the urban fringe. The contemporary rapid changes of the socioeconomic residential segregation pattern under the influence of real estate markets in Santiago de Chile have inspired the proposed poster. The aim of the poster is: 1) to illustrate the new tendencies of socio-spatial segregation patterns in Santiago de Chile; 2) to describe the influencing factors of these patterns; 3) to outline the possible opportunities and risks of these tendencies; and 4) to delineate possible questions of further investigations.