Urbanization and especially megaurbanization is one of the most prominent phenomena and at the same time one of the great challenges of the 21st century as it leads to the evolution of increasingly complex urban settings. Spatially seen urban growth is frequently associated with an expansion of impervious surfaces, the loss of areas with higher infiltration capacities and therewith a severe impact on the ecosystem. Resulting land use/land cover changes frequently lead to an increase of hazards, such as floods, landslides and heat waves. At the same time, the growing amount of people and goods located in hazard prone areas intensifies the vulnerability and finally the risk towards natural forces. The understanding of risk and risk generation is regarded being a fundamental prerequisite for the induction of prevention and mitigation measures. Vulnerability analysis forming one part of the risk analysis in this study is understood as the analysis of physical and social fragility towards and a lack of coping capacities with the hazard. Vulnerability is regarded being a multi-scale and highly dynamic issue that can only be estimated using a variety of input data from different sources and on different spatial scales. The focus of this research is set on the analysis of urban vulnerability towards floods in the case of a river catchment in Santiago de Chile, where regularly occurring flood events pose a threat to people and urban infrastructure. Urban planning does neither consider the flood hazard nor the resulting risk in a sufficient manner. The potential of using planning tools as an instrument to prevent hazards is not tapped. With the goal to raise awareness for the possible lack of coping capacities of the elements at risk, a tool to identify areas with different vulnerabilities is being developed. Using an indicator-based approach, the complex problem of vulnerability is addressed in from an interdisciplinary background. Physical and natural aspects as well as demographic and socio-economic aspects are combined in a comprehensive indicator framework. Methods of GIS, remote sensing and spatial statistics are applied to analyse a variety of data sets from different sources in order to obtain information about the vulnerability of those elements located in the hazard zones, both people and urban infrastructure. One research goal is to investigate the potential use of VHR satellite data for physical and social vulnerability analysis by comparing them with socio-economic census data and results from field surveys. The result from this part of the study is a vulnerability map for the study area considering precipitation events of different probabilities. Using multi-criteria analysis, the indicator values resulting from the analysis of remote sensing, GIS, census data and information obtained during field surveys are rated and analysed consequently. A web-based assessment tool is being developed to allow for an active involvement of stakeholders in the study area and to furthermore provide the results of the study to interested parties.