Global change can cause diseases by different ways: 1/ if temperature increase, life zone of some diseases vectors such as mosquitoes will extend, rising the danger zone of diseases they carry; 2/ climatic variations, like scorching heat, flood or drought, may lead to abnormally high death rate because of starvation or because of hygiene consequences of such events (Besancenot, 2009). But diseases can also be caused by how we man- age global change. For example, install double glazing to reduce emissions of CO2, and/ or use air-conditioning to reduce scorching heat aftermaths may lead to confined spaces that will impact on interior air quality with the risk of induce diseases. Air-conditioning can also constitute a bacteria foster care. Life environment, from biological to physical environment, definitely has an impact on people health. And we can add social environment as the present concern on health at work in France is a witness. When they overlap, these risk factors sometimes induce complex pathologies for whom it is difficult (or impossible) to find the exact cause. An example of this kind of pathology is Sick Building Syndrome, which has been first described in the 70’s (Perdrix, Parat, Liaudy & Maître, 2005). The WHO explained in 1983 that ‘Sick Building Syndrome (SBS) describes a medical condition where people in a building suffer from symptoms of illness or feel unwell for no apparent reason’ (WHO, 1983 p. 3). In France, frequency of such “unexplained” epidemic events seems to increase and, since 2007, there management has been discussed within National Health Watch Institute (Kermarec, 2008). From this reflection, Human Sciences had been invited to work together with National Health Watch Institute to understand: 1/ why management measures sometimes seems to be excessive compared with health situation and 2/ why SBS diagnosis (and subsequently ‘psychogenetic syndrome’) is intolerable for people and therefore, what can we do for people to accept this diagnosis and his managerial consequences. In order to help reflection on SBS management, a qualitative study was conducted after the event in a child care center in Paris area. The aim of this research was to examine a well-managed example. In this child care center, both children and employees developed mild skin symptoms. An environmental cause was finally found, a cleaning problem due to misapplication of household products, which formed a consensus. After a few words on chronology, management critical points will be examined: 1/ how different task groups were formed to answer each identified problems (communication, hypothesis construction, results analysis…); 2/ the place of communication in this case study; 3/ risk representations depending on how local the subject is and according to the moment; 4/ the role of sense of place; and 5/ the need to prepare a local risk management plan. These results cannot be generalized because they come from a single case study. Now, a PhD study is running on management of such multi-causal health events. Both physical and socio-psychological causes will be explored as environmental causes.