The purpose of this chapter is to show the link of evaluation methods such as BPE and planning and design methods such as MAPLE/D illustrated by the example of laboratory buildings. During a two-year research project sponsored by the DFG (Deutsche Forschungsgemeinschaft) the Method for Architectural Planning and Design MAPLE/D was developed. The purpose of the method is to support architects dealing with complexity. Students were already taught to use the method within the framework of university studio teaching successfully. The method is also applicable for practicing / professional architects engaged in complex planning and design processes beginning from the first impulse to the point of the final draft. Against the background of teaching and practice of evaluation, planning, and design methods, two issues emerged: 1. What kind of link is there between MAPLE/D, and BPE? 2. Can BPE give further impetus to MAPLE/D, and vice versa? // To illustrate these issues, the author supervised a thesis of diploma with the title “POE of a laboratory building”. The student applied standard BPE methods and resolved the deficits of the building by using the MAPLE/D method. The POE was conducted as a case study at the Paul-Ehrlich-Institute, Federal Agency for Sera and Vaccines, a large laboratory bio-safety level 1-3 building complex with an area of about 88.000 square meter total floor space. The paper deals with the meta-method MAPLE/D, with the methods of BPE that is to be universalized in Germany, and with the special building type of laboratory buildings with its particular requirements such as fast-changing research environments, bio-safety level codes and standards, and high-level technical building equipment and installation. As a result, the paper will show the characteristics of a POE applied to laboratory buildings and its links to MAPLE/D.