This paper has been progressed in four parts. Part one, traces the transformational trends of socio-physical interaction between the rural-urban ecosystems during the transition of human civilization from agricultural to industrial and from industrial to the post-industrial phases. Part two attempts to identify the salient procedural planning and developmental constraints and conflicts forestalling a sustained integration of rural-urban ecosystems. Part three emphasizes the need for a research oriented methodological approach and utilization of innovative techniques and strategies in order to achieve the integration of rural-urban ecosystems on a sustained basis. Finally, part four highlights the conclusions and recommendations of the study.The study of pertinent literature leads to the inference that all the nations of the world have been and are becoming transformed from traditional agriculture-based civilization to high technology based tertiary civilization, albeit at different rates. It also manifests that the current era of industrialization is of a transitional nature and acts as a bridge between the primary and tertiary civilizations. Various countries of the world have been passing through the peak of the industrial phase with a temporal differential. The journey to the tertiary civilization is successively bringing in its wake a morphological transformation from nodal to aggregative and from aggregative to diffusive pattern, which would finally result in the formation of the global city. However the journey towards the tertiary civilization and the global city would be different for different nations in terms of its timing, ways, means and sociophysical complexion. Different countries would be taxiing from different directions, at different speeds, with different types of technological equipment, in different state of preparedness to embark upon the the socio-physical band wagon of the global city of the twenty-first Century. This uncoordinated development is bringing about differentiated socio-physical changes in the rural-urban human ecosystems on a piecemeal basis. The Global city will indeed be an outcome of the total urbanization - which can perhaps be termed as an era of “rurbanization” - representing an epoch of complete blending of rural-urban ecosystems - rather than rural-urban dichotomy. Nevertheless, a healthy birth of the global city is a highly complex matter and requires a dynamic rather than traditional methodological approach; an interdisciplinary, multi-level participation; and utilization of modern techniques and innovative strategies to deal with the seminal phases of the planning and development processes.