The rising life-expectancy promises a compression of morbidity and the acquisition of several additional years in good health. However, at the same time the risk of developing dementia increases by age. Experts estimate that currently 35.6 million people with dementia live worldwide. This number will double within the next twenty years and will rise to 115.4 million in the year 2050. The symptoms of dementia occur slowly over time, affecting memory, orientation, attention, language and problem solving. In absence of effective medical therapies the individual’s quality of life has been focused by researchers of various professional backgrounds, among them Architects, striving for the design of therapeutic environments.People with dementia’s well-being, functionality and behavior can be supported through dementia-friendly design, which supports autonomy, provides sensory stimulation and promotes social interaction (Cohen & Weisman, 1991). Further, a specific spatial design is necessary: Research indicated that with advancing dementia storing and retrieving a mental visual image becomes increasingly difficult and results in the inability to generate a cognitive map (Poettrich et al., 2009).In nursing homes, the circulation system has been identified as the most determining environmental factor on the resident’s wayfinding abilities: In straight circulation systems, residents were able to find their way better than in any layout that featured a shift in direction, such as L-shapes (Marquardt & Schmieg, 2009). Therefore, people with dementia need direct visual access to all places relevant for them to perform their activities of daily living.Further architectural studies also indicated that people with dementia’s spatial recognition needs to be supported: In order for them to understand the meaning and function of a room it has to be architecturally legible and needs boundaries that clearly separate it from other spaces. A study using the architectural methodology space syntax showed a relationship between the spatial layout of the home and the successful performance of the resident’s activities of daily living (Marquardt et al., 2011). The results imply that enclosed rooms with a clearly legible meaning and function (such as kitchen, hallway, living room) might be better memorized and associated with the spatial layout of the home, resulting in better performance. Floor plan designs that are very open and interconnected might account for difficulties in the spatial representation of people with dementia, increasing the level of dependency on a caregiver.The need to combine two contrary goals striving for evidence-based architectural designs for people with dementia constitutes a challenge for architects: To allow for visual access to all relevant places, and simultaneously to create boundaries to separate spaces one from another in order to render them architecturally legible.