Evidence has been accumulated showing that the objective features of hospital physical environment have an impact on patients’ general well-being. For example, Ulrich (1984) showed that the patients in a room with a view of nature had shorter postoperative hospital stays, recovered with more emotional well-being, and took fewer potent analgesics doses than patients in similar rooms with a view of a brick wall; and Swan, Richardson, and Hutton (2003) found that appealing rooms result in more favorable patients’ judgments of the hospital, stronger intentions to use the hospital again, and stronger intentions to recommend the hospital to others, than typical rooms in the same hospital. Despite this evidence, little attention has been paid to the psychological processes through which this well-known relationship occurs. Using structural equations models, we tested the general hypothesis that the relationship between healthcare physical environment conditions (assessed by two independent architects) and satisfaction with the care unit is mediated by perceptions of quality of physical environment (e.g., design features of hospital inpatient area) and social environment (e.g., interactions with staff, privacy) (Study 1). Results showed that the effect of objective environmental quality (assessed by two independent architects) on satisfaction with care unit is only mediated by perception of quality social environment. We also found that this mediation is moderated by patients’ status.Using multi-group analysis, we found that, as for the total sample, for inpatients the effect is mediated by quality perception of social environment, whereas for outpatients mediation occurs through perception of physical environment. In addition, quality perception of physical and social hospital environment were significantly correlated, a result also found in previous studies.The goal of study 2 was to disentangle the contribution of physical and social environment to the variability of patients’ well-being (measured by satisfaction with care unit and mood). To this end, we planned an experimental study in which we manipulated the perceptions of quality of physical and social environment, opening a window for exploring how much these dimensions affect well-being and how they interact with each other. In this study, we focused on outpatients experience in a healthcare centre. Pre-tested stories of care and pictures of hospital areas were used to manipulate the perception of quality of social environment and physical environment, respectively. In a 3 (social environment: positive vs. neutral vs. negative) X 3 (physical environment: good vs. neutral vs. bad) between participants design, the effect on well-being was analysed. Results of studies 1 and 2 will be discussed.