Evidence-based research has been used in environment behavior research and research results have been utilized in policy and practice since Ulrich’s famous 1984 study of view from patients’ rooms and its relation to their recovery time from surgery. Especially adopted by research in healthcare environments; recent literature reviews revealed that even though there are numerous studies employing evidence based research design, methodologies are mostly confined to a single method leaving multi-method applications in research designs scarce (see Devlin and Arneill, 2003; Ulrich et al. 2004). On the other hand, multi-method approaches allowing for validation and triangulation ensures that the “research results are valid and not a methodological artifact” (Campbell and Fiske, 1959). Therefore in evidence based research, use of multi-methods will not only allow us to examine the same phenomenon from different perspectives but it will also enrich our understanding of the issues under study and strengthen the possibility of implications for practice.This paper argues the need for multi-method research designs in evidence-based research giving examples from completed research that studied the relations between health and the environment. To this end, two different research designs conducted at two different contexts, one at the building scale and the other at the neighborhood scale will be presented: (i) a study investigating the impact of group homes on the health and well being of their elderly residents and the other (ii) investigating the relations between the neighborhood design and the physical activity and social interaction of their residents. Both research studies have employed objective methods including behavior mapping, geographic information systems mapping, space syntax analysis as well as objectively recorded subjective data including surveys and interviews. The process constructing the methodology in multi-method evidence based research and application of these methods during the study will be presented and the implications for further research and evidence based practice will be discussed from the viewpoint of practical considerations, challenges and recommendations. The significance of this research is that it underscores the importance of the use of multi-method and mixed-method research designs in evidence based research and transfers the experience from two comprehensive research studies and attempts to link these with design practice and policy.