From the perspective of neuroscience, the research in restorative environments exposure will enhance our understanding of the neural systems that subserve the human response to the physical world. Functional magnetic resonance imaging (fMRI) is a tool used by a growing number of scientists who seek to investigate the brain mechanisms underlying psychological phenomena (Cacioppo and Decety 2009). Considerable advances in the fMRI technique during the last decade have made fMRI data more precise and reliable. Compared to the traditional questionnaire methods of psychological evaluation, fMRI is far more objective. This technique allows for more objective measures of psychological processes because it can be used to investigate psychological tasks to which people has little or no verbal access (Aue et al. 2009). Up until now the neural mechanisms associated with psychological restoration process related to brain activity haven´t been identified. We explored the neural correlates of restorative environment exposure with functional magnetic resonance imaging (fMRI) while participants viewed photographs with low or high restorative potential (LRP and HRP respectively). Twenty-eigth healthy, right-handed, voluntary male participants were recruited after all responded to an informed written consent. All were mid-to-high socioeconomic level with age averaging 36.18 years (SD 12.46) and scholarity mean of 16.55 years. All procedures were institutional review board approved. Four were eliminated due to: clinical problems (2), claustrophobia (1) and problems with data transfer (1). None had significant neurological or psychiatric history and all answered the SCL 90 symptoms list and the Edinburgh Inventory computerized versions (Gonzalez-Santos et al. 2007; Oldfield, 1971). Twelve participants were assigned to the HRP (36.83 ± 11.52 y.o.a.) and 12 to the LRP group (36.00 ± 13.23 y.o.a.). All MR imaging was performed in a G.E. 3.0T Discovery MR750 with a 32-channel head coil. Activation of the middle frontal gyrus, middle and inferior temporal gyrus, insula, inferior parietal lobe and cuneus was dominant during the view of HRP environments, whereas activation of the superior frontal gyrus, precuneus, parahippocampal gyrus and posterior cingulate was dominant during LRP viewing (p<0.05). Brain areas activations related to involuntary attention were found during the view of HRP environments and brain areas related to directed attention were more active during the view of LRP environments. The results are consistent with the attention restoration theory (Kaplan, 1995). The neuroscience research in restorative environments means a better understanding of the neural basis of environmental transactions that promote the human wellbeing. This understanding contribute to evidence-based design to look the biological bases of human needs, relevant to all built settings and all people (Edelstein 2008).